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Context: India's first chimeric antigen receptor (CAR) T-cell therapy has been approved for the treatment of relapsed-refractory B-cell lymphoma and leukaemia. CAR T-cell therapy is a type of immunotherapy that uses the patient's immune system to fight cancer.
Details
How CAR-T Cell Therapy Works
Significance and Implications
High Response Rate |
βThe 70% overall response rate in patients with relapsed-refractory B-cell lymphomas and leukaemia demonstrates the therapy's effectiveness in treating otherwise difficult-to-treat cases. βHigh response rates indicate that this therapy can offer substantial benefits to patients who might not have responded to conventional treatments, potentially leading to improved survival rates and quality of life. |
Safety Profile |
βNexCAR19's improved safety profile, with reduced cytokine release syndrome (CRS) and absence of neurotoxicity, signifies advancements in managing the side effects associated with CAR-T cell therapy. βEnhanced safety profiles are crucial for minimizing risks and ensuring that patients can undergo treatment with manageable side effects, leading to a higher quality of care. |
Affordability |
βThe significant reduction in the cost of CAR-T cell therapy, from $400,000 to approximately Rs 30-35 lakh per patient, is a game-changer for healthcare accessibility. βLower costs make the therapy more affordable and accessible to a larger population, especially in countries like India where healthcare affordability is a significant concern. βAffordability ensures that a broader range of patients can benefit from this cutting-edge treatment without financial constraints becoming a barrier to access. |
Wider Availability |
βApproval by regulatory authorities and the therapy's availability in government and private hospitals across major cities in India greatly expand its accessibility. βThe wider availability of NexCAR19 means that eligible patients do not have to travel abroad to receive treatment, reducing the burden on patients and their families. |
Conclusion
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