Copyright infringement not intended

Picture Courtesy:  INDIAN EXPRESS

Context:

GLP-1 Drugs is a new class of drugs, revolutionizing the treatment of obesity and type-2 diabetes.  

About GLP-1 Drugs

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that mimic the action of naturally occurring gut hormones called incretins. The body releases incretins after a meal, and they play a vital role in regulating blood sugar and appetite.

GLP-1 drugs like semaglutide and tirzepatide are now in India, revolutionizing obesity treatment with 15-20% weight loss and multiple health benefits.

How does it work?

Boosts Insulin Secretion => They stimulate the pancreas to release insulin when blood sugar is high, helping cells absorb glucose for energy.

Suppresses Glucagon => They inhibit the release of glucagon, a hormone that tells the liver to release stored sugar, thereby preventing excessive glucose in the bloodstream.

Slows Digestion => They slow down the rate at which the stomach empties, which prevents sharp spikes in blood sugar after meals and promotes a feeling of fullness.

Reduces Appetite =>They act on the brain's appetite centers, signaling satiety (the feeling of being full), which leads to reduced food intake and fewer cravings.

Wide-Ranging Health Benefits

Cardiovascular Health => Semaglutide reduces the risk of major adverse cardiovascular events (like heart attacks and strokes) by 20%. Studies show it can reduce heart failure events by up to 69%.

Kidney Disease => These drugs have shown a significant protective effect on kidney function, slowing the progression of chronic kidney disease in diabetic patients.

Liver Health => There is strong evidence that GLP-1 agonists can resolve fatty liver disease in a majority of patients and improve liver fibrosis (scarring).

Obstructive Sleep Apnoea => Tirzepatide received regulatory approval for treating obesity-related obstructive sleep apnoea, a condition where breathing repeatedly stops and starts during sleep.

Neurological and Behavioral Impact => Emerging evidence suggests a potential link to a lower risk of Alzheimer's and other forms of dementia. Reduction in cravings, not just for sugary foods but also for substances like alcohol, indicating potential applications in addiction medicine.

Must Read Articles: 

Obesity Raise Chronic Disease Risk

Double Burden of Obesity and Undernutrition in India

Source: 

INDIAN EXPRESS