IAS Gyan

Daily News Analysis


22nd April, 2024 Health


Source: Hindu

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  • A 65-year-old patient from France, suffering from Parkinson’s plus syndrome, a neurodegenerative disorder with limited surgical options, has undergone a high cervical spinal cord stimulation in a private hospital in Bengaluru.


About Parkinson Plus Syndrome

  • Parkinson Plus Syndrome (PPS), also known as atypical parkinsonism, refers to a group of neurodegenerative disorders characterized by symptoms similar to Parkinson's disease (PD) but with additional features and often faster progression.
  • Distinct Features: PPS encompasses several conditions that share overlapping symptoms with PD but also exhibit additional motor and non-motor manifestations.

Types of Parkinson Plus Syndrome:

  • Multiple System Atrophy (MSA): Characterized by a combination of parkinsonian symptoms, autonomic dysfunction, and cerebellar or pyramidal features.
  • Progressive Supranuclear Palsy (PSP): Presents with vertical gaze palsy, early postural instability, falls, and cognitive impairment.
  • Corticobasal Syndrome (CBS): Manifests with asymmetric parkinsonism, apraxia, alien limb phenomenon, and cortical sensory loss.
  • Lewy Body Dementia (LBD): Involves cognitive impairment, visual hallucinations, fluctuating alertness, and parkinsonian symptoms.


  • Motor Symptoms:
    • Bradykinesia (slowness of movement)
    • Rigidity
    • Tremor (may be less prominent than in PD)
    • Postural instability
  • Non-Motor Symptoms:
    • Autonomic dysfunction (e.g., orthostatic hypotension, urinary incontinence)
    • Cognitive impairment
    • Sleep disturbances (e.g., REM sleep behavior disorder)
    • Psychiatric symptoms (e.g., depression, anxiety)


  • Medications: While some medications used for PD may provide symptomatic relief in PPS, response to treatment is often limited.
  • Physical Therapy: Exercise programs and physical therapy can help improve mobility, balance, and muscle strength.
  • Speech and Swallowing Therapy: Speech therapy can address speech and swallowing difficulties commonly seen in PPS.
  • Supportive Care: Management of non-motor symptoms, including cognitive impairment and autonomic dysfunction, is essential for improving quality of life.

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